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Bristol Myers Squibb Director, Preclinical Cell Therapy in Seattle, Washington

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Summary/Scope

The candidate will direct the scientific aspects of preclinical cell therapy (CAR and TCR) drug development programs in Immune Oncology and Cell Therapy Thematic Center of Excellence. The successful candidate will be responsible for developing key strategies for Bristol Myers Squibb Cell Therapy therapeutic area. The candidate will be responsible for managing and mentoring the key personnel responsible for developing our preclinical Cell therapy pipeline. Expertise in lab-based assessment of immunological read-outs and strong knowledge in immunology, adoptive cell therapy and tumor biology is required. The individual will supervise laboratory-based experiments as well as work with internal and external collaborators. Activities include mentoring junior scientists, delivering lead cell therapy development candidates, executing cell therapy strategy, and carrying out mechanism of action studies for our cell therapy products.

Responsibilities will include, but are not limited to, the following:

  • Development of adoptive cell therapy products including CAR and TCR based products, including next-generation products including gene editing

  • Develop scientific strategy for identifying and evaluating cell therapy drug candidates in preclinical immune oncology assays and models

  • Manage, develop and mentor scientific staff in design and execution of experiments to evaluate Cell therapy drug candidates including drug candidate screening, lead optimization, mechanism of action, preclinical proof of concept studies, biomarker development and translational studies

  • Ownership of the preclinical adoptive T cell targeting strategy and execution, including establishing key academic collaborations

  • Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics, including serving as JRC member.Deliver key insights into challenges of Cellular therapy in solid tumors and insights into how best to address these

  • Serve on internal project teams and committees as scientific functional lead

  • Evaluate and perform due diligence of research programs and technologies

  • Supervise scientific staff

Specific Duties :

  • Supervise and mentor junior Scientists, Associate Scientist(s) and/or Research Associate(s)

  • Lead CAR and TCR biology team meetings, provide scientific guidance and critical analysis of data

  • Critically analyze, interpret, report experimental results; provide insights into research strategies

  • Develop and maintain working relationship with partners and relevant academic collaborators

  • Lead the CAR and TCR biology group in maintaining current awareness in area of expertise; enhance the scientific credibility through contributions to the scientific literature (publications/presentations)

  • Responsible for authorship of non-clinical pharmacology study reports, invention disclosures, sections of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents

  • Oversee Discovery Scientists with the development of in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials

  • Guide Discovery Scientists and project team members to critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps

  • Facilitate cross-functional collaboration across TcoEs and functional areas

  • Lead presentation of data and provide interpretation at key governance meetings

Functional/Scientific/Technical Skills (Qualifications):

  • Ph.D. degree in immunology, tumor biology or cellular biology, or pharmacology with at least 3 years of successful post-doctoral experience, evidenced by a strong publication record, plus a minimum of 12 years of successful experience as a scientist preferably in the biotechnology or pharmaceutical industry setting

  • In depth experience designing and developing primary immune cell assays for drug candidate evaluation and in-depth understanding of immunologic signaling pathways, especially in CAR and TCR biology

  • Knowledge of next-generation engineering concepts with regard to cellular therapies, including but not limited to gene editing and use of switch receptors and costim domains. Gene editing expertise in an industrial setting a plus.

  • Expert in scientific research strategies and methods related to biomarker development and patient stratification

  • Experience with cellular therapy drug development from discovery to IND highly preferred

  • Extensive experience with supervision and mentoring of laboratory scientific staff

  • Ability to design in vitro and in vivo studies with direct translation to drug development, patient stratification and disease indication

  • Excellent communication and interpersonal skills demonstrated in a team environment

  • Excellent team building and teamwork skills and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors

  • Experience with evaluation and due diligence of research programs and technologies

  • Detail-oriented with the ability to identify and implement creative solutions, Ability to prioritize and manage time efficiently

  • Extensive experience with clinical research and an understanding of the research process, validation, and regulations that apply to clinical investigations and laboratory studies that support regulatory submissions is also highly desirable

Discretion/Latitude:

  • Develops strategies.

  • Accountable for success of strategies.

  • Provides input to develop cross functional policies.

  • Recognized as Subject Matter Expert within function.

  • Develop others.

Creativity and Problem Solving:

  • Able to anticipate problems at project level.

  • Proven track record of scientific approach to complex problem solving.

  • Demonstrate in-depth, scientific-directed, innovative thinking.

  • Advises on departmental goals.

  • Recognizes interrelationships of facts/factors, processes, and systems.

  • Recognize risk and propose contingency plans.

Teamwork and Influence:

  • Communicates within the larger organization.

  • Develops constructive relationships across organization to achieve the goals of the function and the business through leadership roles on cross-functional/divisional teams.

Organizational Impact:

  • Beginning to have impact on the performance of multiple departments.

  • Impact is achieved through leading workgroups and contributing to cross-functional teams.

  • Emerging as a leader who influences culture & values.

Behavioral Competencies:

  • Champions change

  • Leads courageously

  • Networking

  • Provides directions

  • Structuring and staffing

  • Thinks strategically

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol Myers Squibb

Req Number: R1529577-en-us

Updated: 2020-09-27 00:28:56.403 UTC

Location: Seattle,Washington

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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